Lineage infidelity following exposure of T lymphoblasts (MOLT-3 cells) to 5-azacytidine.

نویسندگان

  • L J Smith
  • E A McCulloch
چکیده

The appearance on single leukemic blast cells of markers of at least two different lineages has been termed lineage infidelity. MOLT-3 cells, a continuous line of human T lymphoblasts, express T cell markers as defined immunologically with monoclonal antibodies. Following a single exposure to 5-azacytidine, other markers, usually associated with non-T cell lineages, appeared transiently. A stable clone with lineage infidelity was obtained by selection from colonies expressing novel markers. Marker expression followed reproducible kinetics during growth. 5-Azacytidine-treated MOLT-3 subclones may be useful models in the study of lineage infidelity and gene expression.

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عنوان ژورنال:
  • Blood

دوره 63 6  شماره 

صفحات  -

تاریخ انتشار 1984